3rd Edition of International Obesity and Metabolism Conference 2027

Liver related cancer and cirrhosis mortality rates have been reduced globally by the Hepatitis B vaccine however decay still happens. We aimed at determining the prevalence of breakthrough HBV infections and the prevalence of protective levels of vaccine specific anti-HBs antibody titers amongst 15–17-year old adolescents in Kawempe division, Kampala, Uganda. A cross sectional study . Sample size: 288 participants. The results showed; Males;149, Females;139. First dose recipients; 26 , Second dose recipients; 45 and Third dose recipients; 217.Combo test results: Participants at exposure: Acute infections; 4, Chronic infections;3 and vaccine protected 60.Titer test results: Responders ; 22 and non-responders were 43. In conclusion Hepatitis B vaccine 3 dose coverage was good at 75.4% due to introduction of the HBV birth dose and screening of pregnant mothers however more awareness programmes are required. The study revealed an exposure rate of 76.7% for adolescents who had primarily been vaccinated owing this to genetics, Storage, Usage of overdue medicines and incompletion of HBV doses. The prevalence of acute and chronic infections in our study was moderately high at 1.5% and 1.0% respectively due to indulgence in sexual intercourse at a young age plus having many sex partners, Use of drugs, Body piercings and body tattooing plus not knowing the HBV status especially to young mothers. There was a low prevalence of protective anti-body titers at 33.8% possibly due to genetics.